Mayo is a census-designated place in Spartanburg County, South Carolina, United States. The population was 1,592 at the 2010 census.Mayo is located at 35°5′17″N 81°51′4″W / 35.08806°N 81.85111°W / 35.08806; -81.85111.According to the United States Census Bureau, the CDP has a total area of 3.1 square miles, all land.As of the census of 2000, there were 1,842 people, 719 households, and 532 families residing in the CDP. The population density was 590.6 people per square mile. There were 773 housing units at an average density of 247.9/sq mi. The racial makeup of the CDP was 97.29% White, 1.30% African American, 0.33% Native American, 0.49% Asian, 0.22% from other races, and 0.38% from two or more races. Hispanic or Latino of any race were 1.25% of the population.There were 719 households out of which 31.7% had children under the age of 18 living with them, 57.4% were married couples living together, 11.0% had a female householder with no husband present, and 26.0% were non-families.