Spartanburg is the most populous city in and the seat of Spartanburg County, South Carolina, United States, and the 12th-largest city by population in the state. The city of Spartanburg has a municipal population of 37,013, and Spartanburg County has an urban population of 180,786 as of the 2010 census. The Spartanburg Metropolitan Statistical Area, including Spartanburg and Union counties, had a population of 317,057 as of the 2010-2014 American Community Survey 5-Year Estimates.Spartanburg is the second-largest city in the greater Greenville–Spartanburg–Anderson Combined Statistical Area, which has a population of 1,385,045 as of 2014. It is part of a 10-county region of northwestern South Carolina known as "The Upstate," and is located 98 miles northwest of Columbia, 80 miles west of Charlotte, North Carolina, and about 190 miles northeast of Atlanta, Georgia.Spartanburg is a major city in South Carolina. It is the home of Wofford College and the site of headquarters for Denny's.